An Analysis of the Gene Expression Program of Mammalian Neural Progenitor Cells

A diverse range of neural cell types is generated from a pool of dividing stem and progenitor cells in an orderly manner during development. Little is known of the molecular and cellular biology underpinning the intrinsic control of this process. We have used a nonbiased method to purify populations...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-02, Vol.101 (5), p.1374-1379
Main Authors: Livesey, F. J., Young, T. L., Cepko, C. L.
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Cell cycle
Central nervous system
Gene expression
Gene Expression Profiling
Genes
Genetics
Mice
Molecular biology
Multipotent stem cells
Neural stem cells
Neurology
Neurons
Oligonucleotide Array Sequence Analysis
Progenitor cells
Retina
Retina - cytology
Retina - metabolism
RNA, Messenger - analysis
Stem cells
Stem Cells - metabolism
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Summary:A diverse range of neural cell types is generated from a pool of dividing stem and progenitor cells in an orderly manner during development. Little is known of the molecular and cellular biology underpinning the intrinsic control of this process. We have used a nonbiased method to purify populations of neural progenitor cells from the murine CNS to characterize the gene expression program of mammalian retinal progenitor cells. Analysis of these data led to the identification of a core set of >800 transcripts enriched in retinal progenitor cells compared to both their immediate postmitotic progeny and to differentiated neurons. This core set was found to be shared by progenitors in other regions of the developing CNS, with important regional differences in key functional families. In addition to providing an expression fingerprint of this cell type, this set highlights several key aspects of progenitor biology.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0307014101