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Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES

Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2004-01, Vol.67 (1), p.2-4
Main Authors:	Meade-Tollin, L.C, Wijeratne, E.M.K, Cooper, D, Guild, M, Jon, E, Fritz, A, Zhou, G.X, Whitesell, L, Liang, J.Y, Gunatilaka, A.A.L
Format:	Article
Language:	English
Subjects:	Angiogenesis Inhibitors - therapeutic use Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Cells, Cultured Diterpenes - pharmacology Diterpenes, Kaurane Drugs, Chinese Herbal - therapeutic use Endothelial Cells - drug effects General pharmacology Humans Hydrolysis Inhibitory Concentration 50 Isodon - chemistry Male Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy
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container_title	Journal of natural products (Washington, D.C.)
container_volume	67
creator	Meade-Tollin, L.C Wijeratne, E.M.K Cooper, D Guild, M Jon, E Fritz, A Zhou, G.X Whitesell, L Liang, J.Y Gunatilaka, A.A.L
description	Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.
doi_str_mv	10.1021/np0304114
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Angiogenesis Inhibitors - therapeutic use Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Cells, Cultured Diterpenes - pharmacology Diterpenes, Kaurane Drugs, Chinese Herbal - therapeutic use Endothelial Cells - drug effects General pharmacology Humans Hydrolysis Inhibitory Concentration 50 Isodon - chemistry Male Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy
title	Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES
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