Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue

We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals....

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Bibliographic Details
Published in:Physics in medicine & biology 2004-01, Vol.49 (1), p.111-119
Main Authors: Telenkov, Sergey A, Dave, Digant P, Sethuraman, Shriram, Akkin, Taner, Milner, Thomas E
Format: Article
Language:English
Subjects:
Acoustics
Hair
Hot Temperature
Humans
Lasers
Light
Microscopy, Interference - methods
Models, Statistical
Optics and Photonics
Phantoms, Imaging
Scattering, Radiation
Temperature
Time Factors
Tomography
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Summary:We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/49/1/008