TNFalpha potentiates 2-methoxyestradiol-induced mitochondrial death pathway

Ewing sarcoma cells are resistant to TNFalpha-induced cell death and this resistance results from the activation of the transcription factor NF-kappaB. Here, we investigated whether NF-kappaB activation interferes with 2-Me-induced cell death signaling in Ewing sarcoma cells and we examined the effe...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2003-12, Vol.1010, p.159
Main Authors: Djavaheri-Mergny, Mojgan, Wietzerbin, Juana, Rouillard, Dany, Besançon, Françoise
Format: Article
Language:English
Subjects:
2-Methoxyestradiol
Apoptosis - drug effects
Bone Neoplasms
Cell Death - drug effects
Cell Line, Tumor
Drug Synergism
Estradiol - analogs & derivatives
Estradiol - pharmacology
Humans
Mitochondria - drug effects
Mitochondria - pathology
Sarcoma, Ewing
Tumor Necrosis Factor-alpha - pharmacology
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Summary:Ewing sarcoma cells are resistant to TNFalpha-induced cell death and this resistance results from the activation of the transcription factor NF-kappaB. Here, we investigated whether NF-kappaB activation interferes with 2-Me-induced cell death signaling in Ewing sarcoma cells and we examined the effect of treatment of these cells with 2-Me either alone or in combination with TNFalpha. Our results show that TNFa cooperates with 2-Me to induce apoptosis in Ewing tumor cells through mitochondrial cell death signaling. These results suggest that the use of TNFalpha in combination with 2-Me may be beneficial for Ewing tumor treatment.
ISSN:0077-8923