Intracranial calcification and tumoural calcinosis during vitamin D therapy

Extraskeletal calcifications are frequently observed in patients with chronic renal failure. However, clinically, they usually remain silent. In this report, we describe two patients with massive extraskeletal calcifications that caused significant morbidity. The first patient had tumoural calcifica...

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Bibliographic Details
Published in:Nephrology (Carlton, Vic.) Vic.), 2004-04, Vol.9 (2), p.89-93
Main Authors: SEYAHI, NURHAN, APAYDIN, SUHEYLA, SARIYAR, MUZAFFER, SERDENGEÇTI, KAMIL, EREK, EKREM
Format: Article
Language:English
Subjects:
Adolescent
Brain Diseases - etiology
Calcinosis - etiology
chronic renal failure
Humans
Hyperparathyroidism, Secondary - complications
intracranial calcification
Male
Middle Aged
Shoulder
tumoural calcinosis
vitamin D
Vitamin D - adverse effects
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Summary:Extraskeletal calcifications are frequently observed in patients with chronic renal failure. However, clinically, they usually remain silent. In this report, we describe two patients with massive extraskeletal calcifications that caused significant morbidity. The first patient had tumoural calcification located on the shoulder and the second patient had severe neurological symptoms caused by intracranial calcifications. High calcium phosphorus product and severe secondary hyperparathyroidism were present in both patients. Furthermore, they both received inappropriately high doses of active vitamin D, even though they failed to respond to this therapy. We suggest to monitor closely the calcium, phosphorus and parathyroid hormone levels during calcitriol therapy and to perform parathyroidectomy, without delay, in patients who were resistant to calcitriol.
ISSN:1320-5358
1440-1797
DOI:10.1111/j.1440-1797.2003.00237.x