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1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification
Purpose To identify radiation‐induced changes in healthy white‐matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities. Materials and Methods 1H‐MRSI was performed on 10 patients with grade I...
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| Published in: | Journal of magnetic resonance imaging 2004-04, Vol.19 (4), p.379-388 |
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| Language: | English |
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| container_end_page | 388 |
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| container_start_page | 379 |
| container_title | Journal of magnetic resonance imaging |
| container_volume | 19 |
| creator | Lee, Michael C. Pirzkall, Andrea McKnight, Tracy R. Nelson, Sarah J. |
| description | Purpose
To identify radiation‐induced changes in healthy white‐matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities.
Materials and Methods
1H‐MRSI was performed on 10 patients with grade IV gliomas who were to undergo radiation therapy. Choline (Cho), creatine (Cr), and N‐acetylaspartate (NAA) ratios were studied as a function of dose and time. The impact of these spectral changes on a spectral analysis algorithm was evaluated.
Results
The Cho/NAA ratios rose to values of 0.66 ± 0.15, 0.75 ± 0.21, and 0.73 ± 0.15 two months after therapy, compared to immediate post‐therapy values of 0.56 ± 0.15, 0.60 ± 0.16, and 0.61 ± 0.15 for the < 25, 25–50, and > 50 Gy dose groups, respectively. These maxima were followed by a dose‐dependent recovery. A similar trend was found in the Cho/Cr ratio. The automated spectral analysis system incorporated the changing Cho/NAA ratio into a global redefinition of healthy tissue, but did not account for dose‐dependent spatial variations in Cho/NAA ratios.
Conclusion
Radiation significantly alters the spectra of healthy tissues in the first six months after radiotherapy. This suggests that the radiation dose distribution should be considered during analysis of post‐therapy spectra. J. Magn. Reson. Imaging 2004;19:379–388. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.20017 |
| format | article |
| fullrecord | <record><control><sourceid>wiley_pubme</sourceid><recordid>TN_cdi_pubmed_primary_15065160</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JMRI20017</sourcerecordid><originalsourceid>FETCH-LOGICAL-i1347-ddcdd7f6a798be8a9bba3a721a4913f4b264aaa2929d5befc01e50f7e4625ff33</originalsourceid><addsrcrecordid>eNpFkMlO5DAQhi0EYr_MA4z8Agbbie0OtxHQ0IhFYhcXqxKXGUM22UHAhWcndM_AqX6p_kX6CPkl-I7gXO4-NTHsSM6FWSLrQknJpJro5VFzlTEx4WaNbKT0xDkvilytkjWhuFZC83XyIY7Z2eXVjHaeRnABhtC1FL3Hakg0tLTtYgM1g75HiKF9pK9_w4C0gWHAuEcPuoTMYY-tw7ZCCq2joemhGujYAy9DNzrR0dSPhRFqWtWQUvChmi9tkRUPdcLtf3eT3EwPr_eP2enF0Wz_zykLIssNc65yzngNppiUOIGiLCEDIwXkhch8XkqdA4AsZOFUib7iAhX3BnMtlfdZtkl-L3r7l7JBZ_sYGojv9j-I0SAWhtdQ4_vPn9svxPYLsZ0jtidnl7O5GjNskQlpwLfvDMRnq01mlL07P7Ja34rp9OHB3mefsEOAhQ</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Lee, Michael C. ; Pirzkall, Andrea ; McKnight, Tracy R. ; Nelson, Sarah J.</creator><creatorcontrib>Lee, Michael C. ; Pirzkall, Andrea ; McKnight, Tracy R. ; Nelson, Sarah J.</creatorcontrib><description>Purpose
To identify radiation‐induced changes in healthy white‐matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities.
Materials and Methods
1H‐MRSI was performed on 10 patients with grade IV gliomas who were to undergo radiation therapy. Choline (Cho), creatine (Cr), and N‐acetylaspartate (NAA) ratios were studied as a function of dose and time. The impact of these spectral changes on a spectral analysis algorithm was evaluated.
Results
The Cho/NAA ratios rose to values of 0.66 ± 0.15, 0.75 ± 0.21, and 0.73 ± 0.15 two months after therapy, compared to immediate post‐therapy values of 0.56 ± 0.15, 0.60 ± 0.16, and 0.61 ± 0.15 for the < 25, 25–50, and > 50 Gy dose groups, respectively. These maxima were followed by a dose‐dependent recovery. A similar trend was found in the Cho/Cr ratio. The automated spectral analysis system incorporated the changing Cho/NAA ratio into a global redefinition of healthy tissue, but did not account for dose‐dependent spatial variations in Cho/NAA ratios.
Conclusion
Radiation significantly alters the spectra of healthy tissues in the first six months after radiotherapy. This suggests that the radiation dose distribution should be considered during analysis of post‐therapy spectra. J. Magn. Reson. Imaging 2004;19:379–388. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.20017</identifier><identifier>PMID: 15065160</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aspartic Acid - analogs & derivatives ; Aspartic Acid - analysis ; Brain - radiation effects ; Brain Chemistry ; Brain Neoplasms - chemistry ; Brain Neoplasms - radiotherapy ; Choline - analysis ; Creatine - analysis ; Dose-Response Relationship, Radiation ; Female ; glioma ; Glioma - chemistry ; Glioma - radiotherapy ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; radiation therapy ; spectral classification ; treatment effects</subject><ispartof>Journal of magnetic resonance imaging, 2004-04, Vol.19 (4), p.379-388</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15065160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Michael C.</creatorcontrib><creatorcontrib>Pirzkall, Andrea</creatorcontrib><creatorcontrib>McKnight, Tracy R.</creatorcontrib><creatorcontrib>Nelson, Sarah J.</creatorcontrib><title>1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To identify radiation‐induced changes in healthy white‐matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities.
Materials and Methods
1H‐MRSI was performed on 10 patients with grade IV gliomas who were to undergo radiation therapy. Choline (Cho), creatine (Cr), and N‐acetylaspartate (NAA) ratios were studied as a function of dose and time. The impact of these spectral changes on a spectral analysis algorithm was evaluated.
Results
The Cho/NAA ratios rose to values of 0.66 ± 0.15, 0.75 ± 0.21, and 0.73 ± 0.15 two months after therapy, compared to immediate post‐therapy values of 0.56 ± 0.15, 0.60 ± 0.16, and 0.61 ± 0.15 for the < 25, 25–50, and > 50 Gy dose groups, respectively. These maxima were followed by a dose‐dependent recovery. A similar trend was found in the Cho/Cr ratio. The automated spectral analysis system incorporated the changing Cho/NAA ratio into a global redefinition of healthy tissue, but did not account for dose‐dependent spatial variations in Cho/NAA ratios.
Conclusion
Radiation significantly alters the spectra of healthy tissues in the first six months after radiotherapy. This suggests that the radiation dose distribution should be considered during analysis of post‐therapy spectra. J. Magn. Reson. Imaging 2004;19:379–388. © 2004 Wiley‐Liss, Inc.</description><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - analysis</subject><subject>Brain - radiation effects</subject><subject>Brain Chemistry</subject><subject>Brain Neoplasms - chemistry</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Choline - analysis</subject><subject>Creatine - analysis</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>glioma</subject><subject>Glioma - chemistry</subject><subject>Glioma - radiotherapy</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>radiation therapy</subject><subject>spectral classification</subject><subject>treatment effects</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpFkMlO5DAQhi0EYr_MA4z8Agbbie0OtxHQ0IhFYhcXqxKXGUM22UHAhWcndM_AqX6p_kX6CPkl-I7gXO4-NTHsSM6FWSLrQknJpJro5VFzlTEx4WaNbKT0xDkvilytkjWhuFZC83XyIY7Z2eXVjHaeRnABhtC1FL3Hakg0tLTtYgM1g75HiKF9pK9_w4C0gWHAuEcPuoTMYY-tw7ZCCq2joemhGujYAy9DNzrR0dSPhRFqWtWQUvChmi9tkRUPdcLtf3eT3EwPr_eP2enF0Wz_zykLIssNc65yzngNppiUOIGiLCEDIwXkhch8XkqdA4AsZOFUib7iAhX3BnMtlfdZtkl-L3r7l7JBZ_sYGojv9j-I0SAWhtdQ4_vPn9svxPYLsZ0jtidnl7O5GjNskQlpwLfvDMRnq01mlL07P7Ja34rp9OHB3mefsEOAhQ</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Lee, Michael C.</creator><creator>Pirzkall, Andrea</creator><creator>McKnight, Tracy R.</creator><creator>Nelson, Sarah J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200404</creationdate><title>1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification</title><author>Lee, Michael C. ; Pirzkall, Andrea ; McKnight, Tracy R. ; Nelson, Sarah J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1347-ddcdd7f6a798be8a9bba3a721a4913f4b264aaa2929d5befc01e50f7e4625ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - analysis</topic><topic>Brain - radiation effects</topic><topic>Brain Chemistry</topic><topic>Brain Neoplasms - chemistry</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Choline - analysis</topic><topic>Creatine - analysis</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>glioma</topic><topic>Glioma - chemistry</topic><topic>Glioma - radiotherapy</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>radiation therapy</topic><topic>spectral classification</topic><topic>treatment effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Michael C.</creatorcontrib><creatorcontrib>Pirzkall, Andrea</creatorcontrib><creatorcontrib>McKnight, Tracy R.</creatorcontrib><creatorcontrib>Nelson, Sarah J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Michael C.</au><au>Pirzkall, Andrea</au><au>McKnight, Tracy R.</au><au>Nelson, Sarah J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2004-04</date><risdate>2004</risdate><volume>19</volume><issue>4</issue><spage>379</spage><epage>388</epage><pages>379-388</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To identify radiation‐induced changes in healthy white‐matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities.
Materials and Methods
1H‐MRSI was performed on 10 patients with grade IV gliomas who were to undergo radiation therapy. Choline (Cho), creatine (Cr), and N‐acetylaspartate (NAA) ratios were studied as a function of dose and time. The impact of these spectral changes on a spectral analysis algorithm was evaluated.
Results
The Cho/NAA ratios rose to values of 0.66 ± 0.15, 0.75 ± 0.21, and 0.73 ± 0.15 two months after therapy, compared to immediate post‐therapy values of 0.56 ± 0.15, 0.60 ± 0.16, and 0.61 ± 0.15 for the < 25, 25–50, and > 50 Gy dose groups, respectively. These maxima were followed by a dose‐dependent recovery. A similar trend was found in the Cho/Cr ratio. The automated spectral analysis system incorporated the changing Cho/NAA ratio into a global redefinition of healthy tissue, but did not account for dose‐dependent spatial variations in Cho/NAA ratios.
Conclusion
Radiation significantly alters the spectra of healthy tissues in the first six months after radiotherapy. This suggests that the radiation dose distribution should be considered during analysis of post‐therapy spectra. J. Magn. Reson. Imaging 2004;19:379–388. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15065160</pmid><doi>10.1002/jmri.20017</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2004-04, Vol.19 (4), p.379-388 |
| issn | 1053-1807 1522-2586 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Brain - radiation effects Brain Chemistry Brain Neoplasms - chemistry Brain Neoplasms - radiotherapy Choline - analysis Creatine - analysis Dose-Response Relationship, Radiation Female glioma Glioma - chemistry Glioma - radiotherapy Humans Magnetic Resonance Spectroscopy Male Middle Aged radiation therapy spectral classification treatment effects |
| title | 1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification |
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