In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study

Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% )...

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Bibliographic Details
Published in:Haematologica (Roma) 2004-05, Vol.89 (5), p.634
Main Authors: Leone, G, Rutella, S, Voso, MT, Fianchi, L, Scardocci, A, Pagano, L
Format: Article
Language:English
Subjects:
Aged
Aminoglycosides - therapeutic use
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Humanized
Antigens, CD - immunology
Drug Therapy, Combination
Granulocyte Colony-Stimulating Factor - therapeutic use
Humans
Immunotoxins - therapeutic use
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - immunology
Pilot Projects
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Summary:Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complete remission, 2 patients had a partial remission and the other 2 were resistant.
ISSN:0390-6078
1592-8721