Detection of Functional Platelet-Activating Factor Receptors on Leukemic B Cells of Chronic Lymphocytic Leukemic Patients

Although platelet-activating factor receptors (PAF-R) are reported on normal B cells, few results are available concerning leukemic ones. We demonstrated functional PAF-R on cell and nuclear surfaces of leukemic B cells of chronic lymphocytic leukemic (CLL) patients. Analysis of 102 patients reveale...

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Bibliographic Details
Published in:Leukemia & lymphoma 2004-03, Vol.45 (3), p.515-518
Main Authors: Denizot, Y, Donnard, M, Guglielmi, L, Faucher, JL, Jaccard, A, Bordessoule, D, Trimoreau, F
Format: Article
Language:English
Subjects:
Aged
B-Lymphocytes - chemistry
B-Lymphocytes - immunology
B-Lymphocytes - pathology
cAMP
Case-Control Studies
Cell Membrane - chemistry
Chronic B cell leukemia
Female
Humans
IL-4
Immunology
Interleukin-4 - blood
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Life Sciences
Lymphocyte Activation
Male
Nuclear Envelope - chemistry
PAF receptors
Platelet Membrane Glycoproteins - analysis
Proliferation
Receptors, G-Protein-Coupled - analysis
Transforming Growth Factor beta - blood
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Summary:Although platelet-activating factor receptors (PAF-R) are reported on normal B cells, few results are available concerning leukemic ones. We demonstrated functional PAF-R on cell and nuclear surfaces of leukemic B cells of chronic lymphocytic leukemic (CLL) patients. Analysis of 102 patients revealed dramatic differences for their membrane PAF-R expression, a result that might be related to their plasma IL-4 levels. In the light of the potent immunoregulatory role of PAF on B cell physiology, it is suggested that the presence or absence of PAF-R on leukemic B cells may profoundly affect their in vivo behavior.
ISSN:1042-8194
1029-2403
DOI:10.1080/1042819032000141293