Pentacyclic triterpenoid esters from the fruits of Bruguiera cylindrica

Six new pentacyclic triterpenoid esters (1-6) together with 3alpha- and 3beta-taraxerol were isolated from the fruits of Bruguiera cylindrica. The structures of the new compounds were characterized as 3alpha-E-feruloyltaraxerol (1), 3alpha-Z-feruloyltaraxerol (2), 3beta-E-feruloyltaraxerol (3), 3bet...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-05, Vol.67 (5), p.886-888
Main Authors: Laphookhieo, S, Karalai, C, Ponglimanont, C, Chantrapromma, K
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
Esters
Fruit - chemistry
General pharmacology
Humans
Inhibitory Concentration 50
KB Cells
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Rhizophoraceae - chemistry
Stereoisomerism
Thailand
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Tumor Cells, Cultured
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Summary:Six new pentacyclic triterpenoid esters (1-6) together with 3alpha- and 3beta-taraxerol were isolated from the fruits of Bruguiera cylindrica. The structures of the new compounds were characterized as 3alpha-E-feruloyltaraxerol (1), 3alpha-Z-feruloyltaraxerol (2), 3beta-E-feruloyltaraxerol (3), 3beta-Z-feruloyltaraxerol (4), 3alpha-E-coumaroyltaraxerol (5), and 3alpha-Z-coumaroyltaraxerol (6), respectively. Compounds 2 and 6 exhibited weak cytotoxicity against the NCI-H187 cell line.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0305122