Antifungal Cyclopentenediones from Piper coruscans

Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and m...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-06, Vol.126 (22), p.6872-6873
Main Authors: LI, Xing-Cong, FERREIRA, Daneel, JACOB, Melissa R., ZHANG, Qifeng, KHAN, Shabana I., ELSOHLY, Hala N., NAGLE, Dale G., SMILLIE, Troy J., KHAN, Ikhlas A., WALKER, Larry A., CLARK, Alice M.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Candida albicans - drug effects
Chemistry
Cryptococcus neoformans - drug effects
Cyclopentanes - chemical synthesis
Cyclopentanes - chemistry
Cyclopentanes - pharmacology
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Organic chemistry
Pharmacology. Drug treatments
Piper - chemistry
Preparations and properties
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Summary:Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and may serve as a template for a new class of antifungal agents.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja048081c