FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604: I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties

FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis i...

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Published in:Journal of antibiotics 2004/04/25, Vol.57(4), pp.253-259
Main Authors: HATORI, HIDETAKA, SHIBATA, TOSHIHIRO, TSURUMI, YASUHISA, NAKANISHI, TOMOKO, KATSUOKA, MASAAKI, OHTSU, YOSHIHIRO, SAKAMOTO, KAZUTOSHI, TAKASE, SHIGEHIRO, UEDA, HIROTSUGU, HINO, MOTOHIRO, FUJII, TAKASHI
Format: Article
Language:English
Subjects:
Anticholesteremic Agents - chemistry
Anticholesteremic Agents - isolation & purification
Anticholesteremic Agents - metabolism
Anticholesteremic Agents - pharmacology
Ascomycota - chemistry
Ascomycota - metabolism
Aspergillus fumigatus - drug effects
Candida albicans - drug effects
Cell Line, Tumor
Cholesterol - analogs & derivatives
Cholesterol - chemical synthesis
Cholesterol - chemistry
Cholesterol - isolation & purification
Cholesterol - pharmacology
Fermentation
Humans
Inhibitory Concentration 50
Molecular Structure
Molecular Weight
Nuclear Magnetic Resonance, Biomolecular
Spectrometry, Mass, Fast Atom Bombardment
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Summary:FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis in human hepatoma cell line Hep G2. These compounds also have in vitro antifungal activity against Candida albicans and Aspergillus fumigatus.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.57.253