Brain hypoperfusion: a critical factor in vascular dementia

Subcortical ischemic vascular dementia is a relatively common form of dementia. Anatomical changes of ageing in the brain arteries predispose the elderly to the effects of hypotension. Depending on their circulatory pattern, particular regions of the brain are susceptible to ischemic hypoperfusive l...

Full description

Saved in:
Bibliographic Details
Published in:Neurological research (New York) 2004-07, Vol.26 (5), p.454-458
Main Author: Roman, G C
Format: Article
Language:English
Subjects:
Age Factors
BINSWANGER DISEASE
Brain - blood supply
Brain - pathology
Brain - physiopathology
CARDIAC SURGERY
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - pathology
Cerebrovascular Disorders - physiopathology
COGNITION
Cognition Disorders - etiology
Cognition Disorders - pathology
Cognition Disorders - physiopathology
CONGESTIVE HEART FAILURE
Coronary Artery Bypass - adverse effects
Dementia
Dementia, Vascular - etiology
Dementia, Vascular - pathology
Dementia, Vascular - physiopathology
Humans
HYPOTENSION
Hypotension - complications
Hypotension - physiopathology
Neural Pathways - blood supply
Neural Pathways - pathology
Neural Pathways - physiopathology
STROKE
VASCULAR DEMENTIA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Subcortical ischemic vascular dementia is a relatively common form of dementia. Anatomical changes of ageing in the brain arteries predispose the elderly to the effects of hypotension. Depending on their circulatory pattern, particular regions of the brain are susceptible to ischemic hypoperfusive lesions. These regions include the periventricular white matter, basal ganglia, and hippocampus. Interruption of prefrontal-basal ganglia circuits important for cognition and memory may result from these lesions. Hypotension and hypoperfusion explain the high risk for the development of cognitive impairment and vascular dementia in older patients affected by orthostatic hypotension, congestive heart failure, as well as in those undergoing surgical procedures such as hip and knee replacement and coronary artery bypass graft (CABG). Recognition of the susceptibility of elderly subjects to cerebral lesions induced by hypoperfusion should result in appropriate preventive measures and better treatment.
ISSN:0161-6412
1743-1328
DOI:10.1179/016164104225017686