Movement disorders in childhood: therapeutic update

Abnormal movements are not uncommon in childhood. Due to the severity of the abnormal movements or to the functional disability, a medical treatment is often required; the wide range of available pharmacological molecules and the absence of therapeutic consensus highlight the limited efficacy of the...

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Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2004-08, Vol.11 (8), p.951
Main Authors: Roubertie, A, Leydet, J, Rivier, F, Humbertclaude, V, Cheminal, R, Echenne, B
Format: Article
Language:fre
Subjects:
Anti-Dyskinesia Agents - therapeutic use
Baclofen - therapeutic use
Botulinum Toxins, Type A - therapeutic use
Child
Consensus
Electric Stimulation Therapy
Globus Pallidus - surgery
Humans
Movement Disorders - diagnosis
Movement Disorders - epidemiology
Movement Disorders - etiology
Movement Disorders - therapy
Muscle Relaxants, Central - therapeutic use
Neuromuscular Agents - therapeutic use
Patient Selection
Pediatrics - methods
Pediatrics - trends
Practice Guidelines as Topic
Research Design - standards
Tetrabenazine - therapeutic use
Treatment Outcome
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Summary:Abnormal movements are not uncommon in childhood. Due to the severity of the abnormal movements or to the functional disability, a medical treatment is often required; the wide range of available pharmacological molecules and the absence of therapeutic consensus highlight the limited efficacy of the medical treatment on dystonic or athetoid movements, or severe tic disorders. The recent identification of the enzymatic defect implicated in metabolic diseases led to the development of specific treatment for newly recognized disorders, with more or less interesting results (creatine ou biotine supplementation). Recent progress in functional neurosurgery opened new fields in the treatment of movement disorders. Intrathecal baclofen was proved effective in the treatment of secondary dystonia, especially in patients with cerebral palsy. Deep brain stimulation is now an established therapy for patients with a generalized dystonic syndrome. Given the successful results of pallidal stimulation in dystonia, the indication of this procedure has been discussed in other types of abnormal movements.
ISSN:0929-693X
DOI:10.1016/j.arcped.2004.01.009