Ischemic Stroke: “Acidotoxicity” Is a Perpetrator

Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia.

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Bibliographic Details
Published in:Cell 2004-09, Vol.118 (6), p.665-666
Main Authors: Huang, Yangzhong, McNamara, James O.
Format: Article
Language:English
Subjects:
Acidosis - etiology
Acidosis - metabolism
Acidosis - physiopathology
Animals
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Brain Ischemia - physiopathology
Excitatory Amino Acid Antagonists - pharmacology
Excitatory Amino Acid Antagonists - therapeutic use
Glutamic Acid - metabolism
Glutamic Acid - toxicity
Humans
Nerve Degeneration - drug therapy
Nerve Degeneration - etiology
Nerve Degeneration - physiopathology
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Receptors, Glutamate - drug effects
Receptors, Glutamate - metabolism
Stroke - drug therapy
Stroke - metabolism
Stroke - physiopathology
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Description
Summary:Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2004.09.004