BCL-6-positive Human Herpesvirus 8-associated Solid Lymphoma Arising from Liver and Spleen as Multiple Nodular Lesions

We report a case of BCL-6-positive B cell lymphoma with human herpesvirus 8 (HHV-8) infection. A human immunodeficiency virus-infected patient developed a diffuse large B cell lymphoma, which was found exclusively in the liver and spleen with the absence of lymphadenopathy and effusion in any body c...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia & lymphoma 2004-10, Vol.45 (10), p.2169-2172
Main Authors: Hasegawa, Hideki, Katano, Harutaka, Tanno, Masataka, Masuo, Shigeru, Ae, Takako, Sato, Yuko, Takahashi, Hidehiro, Iwasaki, Takuya, Kurata, Takeshi, Sata, Tetsutaro
Format: Article
Language:English
Subjects:
AIDS
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
BCL-6
DNA-Binding Proteins - analysis
Germinal Center - pathology
Germinal Center - virology
Herpesviridae Infections - complications
Herpesvirus 8, Human
HHV-8
HIV Infections - complications
Human herpesvirus 8
Humans
Liver Neoplasms - pathology
Liver Neoplasms - virology
Lymph Nodes - pathology
Lymphoma, B-Cell - pathology
Lymphoma, B-Cell - virology
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Large B-Cell, Diffuse - virology
Male
Malignant lymphoma
Middle Aged
Proto-Oncogene Proteins c-bcl-6
Remission Induction
Splenic Neoplasms - pathology
Splenic Neoplasms - virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a case of BCL-6-positive B cell lymphoma with human herpesvirus 8 (HHV-8) infection. A human immunodeficiency virus-infected patient developed a diffuse large B cell lymphoma, which was found exclusively in the liver and spleen with the absence of lymphadenopathy and effusion in any body cavities. The lymphoma cells were composed of medium to large-sized cells positive for CD20, CD45, and BCL-6, and negative for epithelial cell membrane antigen, CD30, CD45RO, and CD138/syndecan-1, suggesting a germinal center B cell origin. The patient was serologically positive for HHV-8, and HHV-8 was detected in the liver biopsy tissue both by polymerase chain reaction and by immunohistochemistry for HHV-8-encoded latency-associated nuclear antigen. Other HHV-8-associated diseases, such as Kaposi's sarcoma, primary effusion lymphoma, or multicentric Castleman's disease were not detected in the patient. Chemotherapy was effective and reduced the size of the lymphoma dramatically. This is the first case report of a germinal center B cell-originating lymphoma with HHV-8 infection.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190410001723241