Modelling of post-irradiation accelerated repopulation in squamous cell carcinomas

The mechanisms postulated to be responsible for the accelerated repopulation of squamous cell carcinomas during radiotherapy are the loss of asymmetry of stem cell division, acceleration of stem cell division, abortive division and/or recruitment of the non-cycling cell with proliferative capacity....

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Bibliographic Details
Published in:Physics in medicine & biology 2004-08, Vol.49 (16), p.3767-3779
Main Authors: Marcu, L, Doorn, T van, Olver, I
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - radiotherapy
Cell Cycle - radiation effects
Cell Division
Cell Proliferation - radiation effects
Cell Survival - radiation effects
Dose Fractionation, Radiation
Head and Neck Neoplasms - radiotherapy
Humans
Models, Theoretical
Radiation
Radiation Tolerance
Radiotherapy - methods
Radiotherapy Dosage
Stem Cells - metabolism
Stem Cells - radiation effects
Time Factors
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Summary:The mechanisms postulated to be responsible for the accelerated repopulation of squamous cell carcinomas during radiotherapy are the loss of asymmetry of stem cell division, acceleration of stem cell division, abortive division and/or recruitment of the non-cycling cell with proliferative capacity. Although accelerated repopulation was observed with recruitment and accelerated cell cycles, it was not sufficient to cause an observable change to the survival curve. However, modelling the loss of asymmetry in stem cell division has reshaped the curve with a 'growth' shoulder. Cell recruitment was not found to be a major contributor to accelerated tumour repopulation. A more significant contribution was provided through the multiplication of surviving tumour stem cells during radiotherapy, by reducing their cell cycle time, and due to loss of asymmetry of stem cell division.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/49/16/021