An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa

Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective eff...

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Bibliographic Details
Published in:Archives of pharmacal research 2004-09, Vol.27 (9), p.944
Main Authors: Park, Eun-Jeon, Oh, Hyuncheol, Kang, Tai-Hyun, Sohn, Dong-Hwan, Kim, Youn-Chul
Format: Article
Language:English
Subjects:
Agrimonia
Animals
Cell Line, Tumor
Coumarins - chemistry
Coumarins - isolation & purification
Coumarins - pharmacology
Hepatocytes - drug effects
Hepatocytes - physiology
Humans
Male
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Roots
Rats
Rats, Sprague-Dawley
Tacrine - toxicity
tert-Butylhydroperoxide - toxicity
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Summary:Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 +/- 2.8 and 37.7 +/- 1.6 microM, respectively.
ISSN:0253-6269
DOI:10.1007/BF02975848