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An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa
Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective eff...
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| Published in: | Archives of pharmacal research 2004-09, Vol.27 (9), p.944 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_issue | 9 |
| container_start_page | 944 |
| container_title | Archives of pharmacal research |
| container_volume | 27 |
| creator | Park, Eun-Jeon Oh, Hyuncheol Kang, Tai-Hyun Sohn, Dong-Hwan Kim, Youn-Chul |
| description | Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 +/- 2.8 and 37.7 +/- 1.6 microM, respectively. |
| doi_str_mv | 10.1007/BF02975848 |
| format | article |
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(Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 +/- 2.8 and 37.7 +/- 1.6 microM, respectively.</description><identifier>ISSN: 0253-6269</identifier><identifier>DOI: 10.1007/BF02975848</identifier><identifier>PMID: 15473665</identifier><language>eng</language><publisher>Korea (South)</publisher><subject>Agrimonia ; Animals ; Cell Line, Tumor ; Coumarins - chemistry ; Coumarins - isolation & purification ; Coumarins - pharmacology ; Hepatocytes - drug effects ; Hepatocytes - physiology ; Humans ; Male ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Roots ; Rats ; Rats, Sprague-Dawley ; Tacrine - toxicity ; tert-Butylhydroperoxide - toxicity</subject><ispartof>Archives of pharmacal research, 2004-09, Vol.27 (9), p.944</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15473665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Eun-Jeon</creatorcontrib><creatorcontrib>Oh, Hyuncheol</creatorcontrib><creatorcontrib>Kang, Tai-Hyun</creatorcontrib><creatorcontrib>Sohn, Dong-Hwan</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><title>An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa</title><title>Archives of pharmacal research</title><addtitle>Arch Pharm Res</addtitle><description>Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 +/- 2.8 and 37.7 +/- 1.6 microM, respectively.</description><subject>Agrimonia</subject><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Coumarins - chemistry</subject><subject>Coumarins - isolation & purification</subject><subject>Coumarins - pharmacology</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tacrine - toxicity</subject><subject>tert-Butylhydroperoxide - toxicity</subject><issn>0253-6269</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNo1j7tOwzAYhT2AaCksPADyCwR-35MxVLRFqsQCc-XYDjVqYit2QXl7ggjTN5yLzkHojsADAVCPTxuglRIlLy_QEqhghaSyWqDrlD4BmBRCXKEFEVwxKcUSubrHPgUTzp0efI-_fT7io4s6hziE7Ez2Xw7rX_g84smxcxFvKda9xXHwU2qc_WbMLuF2CB2uPyYl9F7j6E8h6Rt02epTcrczV-h98_y23hX71-3Lut4XkUKVi1ZYS6SxjDquG0okAWIqQ7RSqtRcWuvAAgCplNGMcaqgaRvulCOtoYywFbr_643npnP2MA88_P9lP9hoVjY</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Park, Eun-Jeon</creator><creator>Oh, Hyuncheol</creator><creator>Kang, Tai-Hyun</creator><creator>Sohn, Dong-Hwan</creator><creator>Kim, Youn-Chul</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20040901</creationdate><title>An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa</title><author>Park, Eun-Jeon ; Oh, Hyuncheol ; Kang, Tai-Hyun ; Sohn, Dong-Hwan ; Kim, Youn-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-f5dd16cd32e4ab216101c9c1a7778a46dde0d000197ca334270bfb4e7e1fc2313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Agrimonia</topic><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Coumarins - chemistry</topic><topic>Coumarins - isolation & purification</topic><topic>Coumarins - pharmacology</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tacrine - toxicity</topic><topic>tert-Butylhydroperoxide - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Eun-Jeon</creatorcontrib><creatorcontrib>Oh, Hyuncheol</creatorcontrib><creatorcontrib>Kang, Tai-Hyun</creatorcontrib><creatorcontrib>Sohn, Dong-Hwan</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Eun-Jeon</au><au>Oh, Hyuncheol</au><au>Kang, Tai-Hyun</au><au>Sohn, Dong-Hwan</au><au>Kim, Youn-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa</atitle><jtitle>Archives of pharmacal research</jtitle><addtitle>Arch Pharm Res</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>27</volume><issue>9</issue><spage>944</spage><pages>944-</pages><issn>0253-6269</issn><abstract>Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-beta-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 +/- 2.8 and 37.7 +/- 1.6 microM, respectively.</abstract><cop>Korea (South)</cop><pmid>15473665</pmid><doi>10.1007/BF02975848</doi></addata></record> |
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| identifier | ISSN: 0253-6269 |
| ispartof | Archives of pharmacal research, 2004-09, Vol.27 (9), p.944 |
| issn | 0253-6269 |
| language | eng |
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| source | Springer Nature |
| subjects | Agrimonia Animals Cell Line, Tumor Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Hepatocytes - drug effects Hepatocytes - physiology Humans Male Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots Rats Rats, Sprague-Dawley Tacrine - toxicity tert-Butylhydroperoxide - toxicity |
| title | An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa |
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