Nifedipine encapsulated core-shell type nanoparticles based on poly(γ-benzyl L-glutamate) poly(ethylene glycol) diblock copolymers

The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD)...

Full description

Saved in:
Bibliographic Details
Published in:Journal of microencapsulation 2004-06, Vol.21 (4), p.445-453
Main Authors: Jeong, Y.-I., Sun, H.-S., Shim, Y.-H., Kim, C., Park, S.-H., Choi, K.-C., Cho, C.-S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
block copolymer
Calcium Channel Blockers - pharmacology
controlled release
Core-shell type nanoparticle
critical association concentration
Delayed-Action Preparations
Drug Compounding - methods
General pharmacology
Medical sciences
Microscopy, Electron
Nanotechnology
nifedipine
Nifedipine - pharmacology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyethylene Glycols
Polyglutamic Acid - analogs & derivatives
Spectrometry, Fluorescence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was slower in longer PBLG chain length and higher NFD contents than short PBLG chain length and lower drug contents of NFD due to the hydrophobic interaction between PBLG domain and NFD.
ISSN:0265-2048
1464-5246
DOI:10.1080/02652040410001729241