A mass spectrometric investigation of non-covalent interactions between ruthenium complexes and DNA

Electrospray ionisation mass spectrometry was used to investigate reactions between six ruthenium compounds and three different non self-complementary duplex oligonucleotides containing 16 base pairs. Each of the compounds studied formed non-covalent complexes containing between one and five rutheni...

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Published in:Dalton transactions : an international journal of inorganic chemistry 2004-09 (17), p.2683
Main Authors: Urathamakul, Thitima, Beck, Jennifer L, Sheil, Margaret M, Aldrich-Wright, Janice R, Ralph, Stephen F
Format: Article
Language:English
Subjects:
Dactinomycin - chemistry
Daunorubicin - chemistry
DNA - chemistry
Organometallic Compounds - chemistry
Ruthenium - chemistry
Spectrometry, Mass, Electrospray Ionization
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creator Urathamakul, Thitima
Beck, Jennifer L
Sheil, Margaret M
Aldrich-Wright, Janice R
Ralph, Stephen F
description Electrospray ionisation mass spectrometry was used to investigate reactions between six ruthenium compounds and three different non self-complementary duplex oligonucleotides containing 16 base pairs. Each of the compounds studied formed non-covalent complexes containing between one and five ruthenium molecules bound to DNA. Competition experiments involving duplex 16mers and pairs of ruthenium compounds were used to determine the order of relative binding affinities of the metal compounds. Other competition experiments involving ruthenium compounds, and the organic DNA binding agents daunomycin and distamycin, provided information about the sites and modes of DNA binding of the ruthenium compounds.
doi_str_mv 10.1039/b406889k
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ispartof Dalton transactions : an international journal of inorganic chemistry, 2004-09 (17), p.2683
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source Royal Society of Chemistry: Jisc Collections: Journals Archive 1841-2007 (2019-2023)
subjects Dactinomycin - chemistry
Daunorubicin - chemistry
DNA - chemistry
Organometallic Compounds - chemistry
Ruthenium - chemistry
Spectrometry, Mass, Electrospray Ionization
title A mass spectrometric investigation of non-covalent interactions between ruthenium complexes and DNA
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