Evaluation of an Ultrasensitive p24 Antigen Assay as a Potential Alternative to Human Immunodeficiency Virus Type 1 RNA Viral Load Assay in Resource-Limited Settings

An inexpensive enzyme-linked immunosorbent assay method for human immunodeficiency virus type 1 quantitation, ultrasensitive p24 antigen assay (Up24), was compared with RNA viral load assay (VL). Up24 had 100% sensitivity of detection at a viral load of [>/=]30,000, with sensitivity of 46.4% at a...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005, Vol.43 (1), p.506-508
Main Authors: Respess, Richard A, Cachafeiro, Ada, Withum, David, Fiscus, Susan A, Newman, Daniel, Branson, Bernard, Varnier, Oliviero E, Lewis, Kim, Dondero, Timothy J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
HIV Core Protein p24 - blood
HIV Infections - virology
HIV-1 - isolation & purification
HIV-1 - physiology
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Reproducibility of Results
RNA, Viral - blood
Sensitivity and Specificity
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Virology
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Summary:An inexpensive enzyme-linked immunosorbent assay method for human immunodeficiency virus type 1 quantitation, ultrasensitive p24 antigen assay (Up24), was compared with RNA viral load assay (VL). Up24 had 100% sensitivity of detection at a viral load of [>/=]30,000, with sensitivity of 46.4% at a viral load of
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.1.506-508.2005