Glucose Reaction with Fumonisin B1 Partially Reduces Its Toxicity in Swine

Acute and subacute intraperitoneal doses of fumonisin B1 (FB1) were administered to test the efficacy of the FB1−glucose reaction products in detoxifying FB1 in swine. In the acute study at 11 μmol of FB1/kg of body weight, five of six pigs administered FB1 and four of six pigs administered FB1−gluc...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2004-12, Vol.52 (25), p.7732-7739
Main Authors: Fernández-Surumay, Guillermo, Osweiler, Gary D, Yaeger, Michael J, Hauck, Catherine C, Hendrich, Suzanne, Murphy, Patricia A
Format: Article
Language:English
Subjects:
acute toxicity
Animal productions
Animals
Biological and medical sciences
Chemical and Drug Induced Liver Injury
fumonisin B1
Fumonisins - chemistry
Fumonisins - toxicity
Fundamental and applied biological sciences. Psychology
glucose
Glucose - administration & dosage
Glucose - chemistry
intraperitoneal injection
Liver Diseases - prevention & control
Liver Diseases - veterinary
metabolic detoxification
protective effect
Pulmonary Edema - chemically induced
Pulmonary Edema - prevention & control
Pulmonary Edema - veterinary
subacute toxicity
Swine
Swine Diseases - chemically induced
Swine Diseases - prevention & control
Terrestrial animal productions
Vertebrates
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Summary:Acute and subacute intraperitoneal doses of fumonisin B1 (FB1) were administered to test the efficacy of the FB1−glucose reaction products in detoxifying FB1 in swine. In the acute study at 11 μmol of FB1/kg of body weight, five of six pigs administered FB1 and four of six pigs administered FB1−glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate aminotransferase and γ-glutamyltransferase, total cholesterol, and pathological evaluation did not provide evidence of protection against FB1 toxicity by the FB1−glucose reaction products. In the subacute study at 5.5 μmol of FB1/kg of body weight, one pig administered FB1 died from liver damage. Analysis of serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin showed protection against FB1 toxicity by the FB1−glucose reaction products. The levels of sphinganine and sphinganine/sphingosine ratios in serum and liver as well as pathologic findings provided definitive evidence of protection against the FB1 toxic effects by this detoxification procedure (p < 0.05). Keywords: Fumonisin B1; fumonisin B1−glucose; detoxification; swine
ISSN:0021-8561
1520-5118
DOI:10.1021/jf048981c