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Effect of Stimulus Size on the Dynamics of Orientation Selectivity in Macaque V1
1 Center for Neural Science, New York University, New York, New York; and 2 Departments of Neurobiology, Psychology, and Brain Research Institute, University of California, Los Angeles, California Submitted 5 November 2004; accepted in final form 15 February 2005 Previous research has established th...
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| Published in: | Journal of neurophysiology 2005-07, Vol.94 (1), p.799-812 |
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| creator | Xing, Dajun Shapley, Robert M Hawken, Michael J Ringach, Dario L |
| description | 1 Center for Neural Science, New York University, New York, New York; and 2 Departments of Neurobiology, Psychology, and Brain Research Institute, University of California, Los Angeles, California
Submitted 5 November 2004;
accepted in final form 15 February 2005
Previous research has established that orientation selectivity depends to a great extent on suppressive mechanisms in the visual cortex. In this study, we investigated the spatial organization and the time-course of these mechanisms. Stimuli were presented in circular windows of "optimal" and "large" radii. The two stimulus sizes were chosen based on an area-response function measured with drifting gratings at high contrast. The "optimal" size was defined as the smallest radius that elicited the peak response (average value of 0.45°), whereas "large" was defined as two to five times the optimal size. We found that the peak amplitude of tuned enhancement and untuned suppression varied |
| doi_str_mv | 10.1152/jn.01139.2004 |
| format | article |
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Submitted 5 November 2004;
accepted in final form 15 February 2005
Previous research has established that orientation selectivity depends to a great extent on suppressive mechanisms in the visual cortex. In this study, we investigated the spatial organization and the time-course of these mechanisms. Stimuli were presented in circular windows of "optimal" and "large" radii. The two stimulus sizes were chosen based on an area-response function measured with drifting gratings at high contrast. The "optimal" size was defined as the smallest radius that elicited the peak response (average value of 0.45°), whereas "large" was defined as two to five times the optimal size. We found that the peak amplitude of tuned enhancement and untuned suppression varied <10% on average with stimulus radius, indicating that they are mainly concentrated in the classical receptive field. However, tuned suppressionin those cells that showed itwas significantly stronger with large stimuli, indicating that this component has a contribution from beyond the classical receptive field. These results imply that spatial context (in large stimuli) enhances orientation selectivity by increasing tuned suppression. We also characterized the time evolution of enhancement, of untuned suppression, and of tuned suppression. The time-course of tuned suppression was markedly slower in time-to-peak and longer in its persistence than untuned suppression. Therefore tuned suppression is likely to be generated by long-range recurrent connections or cortico-cortical feedback, whereas untuned suppression is mainly generated locally in V1.
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Submitted 5 November 2004;
accepted in final form 15 February 2005
Previous research has established that orientation selectivity depends to a great extent on suppressive mechanisms in the visual cortex. In this study, we investigated the spatial organization and the time-course of these mechanisms. Stimuli were presented in circular windows of "optimal" and "large" radii. The two stimulus sizes were chosen based on an area-response function measured with drifting gratings at high contrast. The "optimal" size was defined as the smallest radius that elicited the peak response (average value of 0.45°), whereas "large" was defined as two to five times the optimal size. We found that the peak amplitude of tuned enhancement and untuned suppression varied <10% on average with stimulus radius, indicating that they are mainly concentrated in the classical receptive field. However, tuned suppressionin those cells that showed itwas significantly stronger with large stimuli, indicating that this component has a contribution from beyond the classical receptive field. These results imply that spatial context (in large stimuli) enhances orientation selectivity by increasing tuned suppression. We also characterized the time evolution of enhancement, of untuned suppression, and of tuned suppression. The time-course of tuned suppression was markedly slower in time-to-peak and longer in its persistence than untuned suppression. Therefore tuned suppression is likely to be generated by long-range recurrent connections or cortico-cortical feedback, whereas untuned suppression is mainly generated locally in V1.
Address for reprint requests and other correspondence: D. Xing, Center for Neural Science, New York Univ., New York, NY 10003 (E-mail: xdj{at}cns.nyu.edu )</description><subject>Animals</subject><subject>Macaca fascicularis</subject><subject>Models, Neurological</subject><subject>Neural Inhibition</subject><subject>Nonlinear Dynamics</subject><subject>Orientation - physiology</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Photic Stimulation - methods</subject><subject>Space Perception - physiology</subject><subject>Time Factors</subject><subject>Visual Cortex - physiology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkM1vEzEQxa0KREPh2GvlE7cN_vb6WLUpIBUVKYWr5XXGjaP9SNdeYPnrcWhQT4jTjGZ-7z3pIXROyZJSyd7v-iWhlJslI0ScoEW5sYpKU79AC0LKzonWp-h1SjtCiJaEvUKnVGpWa8UX6MsqBPAZDwGvc-ymdkp4HX8BHnqct4Cv59510acDcDdG6LPLsfzW0BZZ_B7zjGOPPzvvHifA3-gb9DK4NsHb4zxDX29W91cfq9u7D5-uLm8rLxTLVQ288YoYp5pmw2VovKh9AKkNKB6axtWOcwHaMCF5E9jGSyUV4UFTISgIfobePfnux6Ekp2y7mDy0rethmJJV2tScMPpfkGqulJK8gNUT6MchpRGC3Y-xc-NsKbGHru2ut3-6toeuC39xNJ6aDjbP9LHc5-RtfNj-iCPY_XZOcWiHh_ngZYSlVhtTQPZv8GZq23v4mYvir8DuN4H_Bh8UmUE</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Xing, Dajun</creator><creator>Shapley, Robert M</creator><creator>Hawken, Michael J</creator><creator>Ringach, Dario L</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Effect of Stimulus Size on the Dynamics of Orientation Selectivity in Macaque V1</title><author>Xing, Dajun ; Shapley, Robert M ; Hawken, Michael J ; Ringach, Dario L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-8e3bc609a6bbd35fbc48cfe579e63fbba8a334e792453bf2dc565603f71441e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Macaca fascicularis</topic><topic>Models, Neurological</topic><topic>Neural Inhibition</topic><topic>Nonlinear Dynamics</topic><topic>Orientation - physiology</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Photic Stimulation - methods</topic><topic>Space Perception - physiology</topic><topic>Time Factors</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xing, Dajun</creatorcontrib><creatorcontrib>Shapley, Robert M</creatorcontrib><creatorcontrib>Hawken, Michael J</creatorcontrib><creatorcontrib>Ringach, Dario L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xing, Dajun</au><au>Shapley, Robert M</au><au>Hawken, Michael J</au><au>Ringach, Dario L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Stimulus Size on the Dynamics of Orientation Selectivity in Macaque V1</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>94</volume><issue>1</issue><spage>799</spage><epage>812</epage><pages>799-812</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>1 Center for Neural Science, New York University, New York, New York; and 2 Departments of Neurobiology, Psychology, and Brain Research Institute, University of California, Los Angeles, California
Submitted 5 November 2004;
accepted in final form 15 February 2005
Previous research has established that orientation selectivity depends to a great extent on suppressive mechanisms in the visual cortex. In this study, we investigated the spatial organization and the time-course of these mechanisms. Stimuli were presented in circular windows of "optimal" and "large" radii. The two stimulus sizes were chosen based on an area-response function measured with drifting gratings at high contrast. The "optimal" size was defined as the smallest radius that elicited the peak response (average value of 0.45°), whereas "large" was defined as two to five times the optimal size. We found that the peak amplitude of tuned enhancement and untuned suppression varied <10% on average with stimulus radius, indicating that they are mainly concentrated in the classical receptive field. However, tuned suppressionin those cells that showed itwas significantly stronger with large stimuli, indicating that this component has a contribution from beyond the classical receptive field. These results imply that spatial context (in large stimuli) enhances orientation selectivity by increasing tuned suppression. We also characterized the time evolution of enhancement, of untuned suppression, and of tuned suppression. The time-course of tuned suppression was markedly slower in time-to-peak and longer in its persistence than untuned suppression. Therefore tuned suppression is likely to be generated by long-range recurrent connections or cortico-cortical feedback, whereas untuned suppression is mainly generated locally in V1.
Address for reprint requests and other correspondence: D. Xing, Center for Neural Science, New York Univ., New York, NY 10003 (E-mail: xdj{at}cns.nyu.edu )</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>15728763</pmid><doi>10.1152/jn.01139.2004</doi><tpages>14</tpages></addata></record> |
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| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Animals Macaca fascicularis Models, Neurological Neural Inhibition Nonlinear Dynamics Orientation - physiology Pattern Recognition, Visual - physiology Photic Stimulation - methods Space Perception - physiology Time Factors Visual Cortex - physiology |
| title | Effect of Stimulus Size on the Dynamics of Orientation Selectivity in Macaque V1 |
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