Endothelial cell regulation of matrix metalloproteinases

The process of sprouting angiogenesis requires that the endothelial cells degrade the basement membrane matrix and migrate into the interstitial matrix. Matrix metalloproteinases are enzymes capable of cleaving numerous extracellular matrix proteins. Increased production and activity of matrix metal...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2005-01, Vol.83 (1), p.1-7
Main Author: Haas, Tara L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood vessels and receptors
Endothelial Cells - enzymology
Endothelial Cells - physiology
Enzyme Induction - physiology
Fundamental and applied biological sciences. Psychology
Humans
Matrix Metalloproteinases - biosynthesis
Matrix Metalloproteinases - physiology
Neovascularization, Physiologic - physiology
Signal Transduction - physiology
Stress, Mechanical
Transcription, Genetic - physiology
Vertebrates: cardiovascular system
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Summary:The process of sprouting angiogenesis requires that the endothelial cells degrade the basement membrane matrix and migrate into the interstitial matrix. Matrix metalloproteinases are enzymes capable of cleaving numerous extracellular matrix proteins. Increased production and activity of matrix metalloproteinases in any cell type is associated with a more migratory and invasive phenotype. This paper describes results of recent in-vitro studies of the regulation of transcription and activation of MMP-2 and MT1-MMP in endothelial cells, as well as studies that examined roles of matrix metalloproteinases in activity-induced angiogenesis.Key words: proteolysis, extracellular matrix, angiogenesis, mechanotransduction.
ISSN:0008-4212
1205-7541
DOI:10.1139/y04-120