Enhanced immunopathology induced by very virulent infectious bursal disease virus

Immunohistochemical and flow cytometric analyses of the bursa, spleen and thymus following infection with the very virulent infectious bursal disease virus (vvIBDV) strain UK661 revealed discrete differences from classical virulent infectious bursal disease virus strains. Bu-1 + , immunoglobulin (Ig...

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Bibliographic Details
Published in:Avian pathology 2005-02, Vol.34 (1), p.4-14
Main Authors: Williams, A.E, Davison, T.F
Format: Article
Language:English
Subjects:
Animal diseases
Animals
B-lymphocytes
Birds
Birnaviridae Infections - immunology
Birnaviridae Infections - pathology
Birnaviridae Infections - veterinary
Birnaviridae Infections - virology
bursa of Fabricius
Bursa of Fabricius - pathology
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Chickens
chicks
Flow Cytometry
immunoglobulin G
immunoglobulin M
Immunohistochemistry
immunopathology
infectious bursal disease
Infectious bursal disease virus
Infectious bursal disease virus - pathogenicity
Lymphoid Tissue - pathology
macrophages
Poultry Diseases - immunology
Poultry Diseases - pathology
Poultry Diseases - virology
spleen
Spleen - pathology
strains
T-lymphocytes
thymus gland
Thymus Gland - pathology
Time Factors
Virulence
Viruses
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Summary:Immunohistochemical and flow cytometric analyses of the bursa, spleen and thymus following infection with the very virulent infectious bursal disease virus (vvIBDV) strain UK661 revealed discrete differences from classical virulent infectious bursal disease virus strains. Bu-1 + , immunoglobulin (Ig)M + and IgG + cells were all depleted from the bursa, spleen and thymus, suggesting loss of both immature and mature B lymphocytes. Small numbers of Bu-1 + cells repopulated the bursa 14 days post-infection but few of these expressed IgM or IgG. A transient increase in macrophages at 3 to 5 days post-infection was followed by a later influx of CD4 + and CD8 + T cells into the bursa. Loss of cortical thymocytes during the acute phase of infection suggested disruption of the T-cell system. The results showed that vvIBDV strain UK661 caused earlier and more severe pathology than classical virulent strains of infectious bursal disease virus. The marked influx of T cells into the infected bursa indicates that cell-mediated immunity is likely to be important in the clearance of vvIBDV.
ISSN:0307-9457
1465-3338
DOI:10.1080/03079450400025364