Analysis of the Genetic Structure of Nontypeable Pneumococcal Strains Isolated from Conjunctiva

More than 50% of the nontypeable (NT) pneumococcal strains received in our laboratory for reference purposes are isolated in sporadic cases of conjunctivitis. To determine the genetic structure of the population of these NT conjunctival strains, we analyzed 75 pneumococci (40 NT and 35 typeable) iso...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-04, Vol.43 (4), p.1694-1698
Main Authors: Berrón, Sonsoles, Fenoll, Asunción, Ortega, Montserrat, Arellano, Noemí, Casal, Julio
Format: Article
Language:English
Subjects:
Bacterial Typing Techniques
Bacteriology
Biological and medical sciences
Conjunctiva - microbiology
Conjunctivitis, Bacterial - microbiology
Electrophoresis, Gel, Pulsed-Field
Fundamental and applied biological sciences. Psychology
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Pneumococcal Infections - microbiology
Serotyping
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - isolation & purification
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Summary:More than 50% of the nontypeable (NT) pneumococcal strains received in our laboratory for reference purposes are isolated in sporadic cases of conjunctivitis. To determine the genetic structure of the population of these NT conjunctival strains, we analyzed 75 pneumococci (40 NT and 35 typeable) isolated from conjunctivas and 30 (15 NT and 15 typeable) isolated from other sources. The NT and typeable conjunctival strains grouped in separate clusters, whereas NT and typeable pneumococci isolated from other sources were similarly distributed. NT conjunctival strains belonged to two well-differentiated clonal lineages. The first, represented by three newly described sequence types, featured fully antibiotic susceptible strains and appeared to be characteristic of conjunctival tissue; the second, represented by the previously described ST344, had a pattern of multiresistance to penicillin, tetracycline, and erythromycin and shared a genetic background with some NT strains isolated from other sources.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.43.4.1694-1698.2005