Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy

The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important issue, we have instituted a rapid autopsy protocol for the collection of high quality tissues from patients...

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Bibliographic Details
Published in:Cancer biology & therapy 2005-05, Vol.4 (5), p.548-554
Main Authors: Embuscado, Erlinda E., Laheru, Daniel, Ricci, Francesca, Yun, Ki Jung, de Boom Witzel, Sten, Seigel, Allison, Flickinger, Katie, Hidalgo, Manuel, Bova, G. Steven, Iacobuzio-Donahue, Christine A.
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Aged, 80 and over
Animals
Autopsy
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
DNA Mutational Analysis
Female
Gene Deletion
Homozygote
Humans
Immunohistochemistry
Landes
Male
Mice
Mice, Nude
Microdissection
Middle Aged
Mutation, Missense
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasm Proteins - genetics
Neoplasm Transplantation
Organogenesis
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Proteins
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins p21(ras)
ras Proteins
Sequence Analysis, DNA
Smad4 Protein - genetics
Time Factors
Transplantation, Heterologous
Tumor Suppressor Protein p53 - genetics
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Summary:The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important issue, we have instituted a rapid autopsy protocol for the collection of high quality tissues from patients with metastatic pancreatic cancer, called the Gastrointestinal Cancer Rapid Medical Donation Program (GICRMDP). At the time of preparation of this manuscript, 20 patients with metastatic pancreatic cancer and one patient with metastatic colon cancer have undergone a rapid autopsy in association with the GICRMDP. The average time interval achieved for these 21 patients was 8.0 hours, with more than 500 individual samples of matched high quality primary and metastatic pancreatic cancer tissues, peritoneal/pleural fluid and blood obtained so far. For the first four patients in which the autopsy was performed in
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.4.5.1663