Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships

In the present article, tyrosinase inhibition studies on fifteen diterpenoid alkaloids, with lycoctonine skeleton, and their semisynthetic derivatives 1-15 and six napelline-type compounds 16-21 are discussed. Their structure-activity relationship for tyrosinase inhibition is also discussed. These a...

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Bibliographic Details
Published in:Natural product research 2005-07, Vol.19 (5), p.517-522
Main Authors: Sultankhodzhaev, Mukhlis N., Hassan Khan, Mahmud Tareq, Moin, Mahera, Choudhary, M. Iqbal, Atta-ur-Rahman
Format: Article
Language:English
Subjects:
Aconitum
Alkaloids - chemistry
Alkaloids - pharmacology
Delphinium
Diterpenes - chemistry
Diterpenes - pharmacology
Diterpenoid alkaloids
Lappaconitine HBr
Lycoctonine
Molecular Structure
Monophenol Monooxygenase - antagonists & inhibitors
Structure-Activity Relationship
Tyrosinase inhibitors
Vitiligo
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Summary:In the present article, tyrosinase inhibition studies on fifteen diterpenoid alkaloids, with lycoctonine skeleton, and their semisynthetic derivatives 1-15 and six napelline-type compounds 16-21 are discussed. Their structure-activity relationship for tyrosinase inhibition is also discussed. These activities were compared with two referenced tyrosinase inhibitors, kojic acid and L-mimosine. The study showed that lappaconitine HBr (1) is the most potent member of the series (IC 50  = 13.30 μM).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410512331330585