labdane diterpene glucoside from the rhizomes of Curcuma mangga

A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxyc...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-07, Vol.68 (7), p.1090-1093
Main Authors: Abas, F, Lajis, N.H, Shaari, K, Israf, D.A, Stanslas, J, Yusuf, U.K, Raof, S.M
Format: Article
Language:English
Subjects:
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
antioxidant activity
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biological and medical sciences
chemical reactions
chemical structure
cultured cells
Curcuma
Curcuma - chemistry
Curcuma mangga
curcumanggoside
cytotoxicity
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
diterpenoids
Drug Screening Assays, Antitumor
General pharmacology
glucosides
Glucosides - chemistry
Glucosides - isolation & purification
Glucosides - pharmacology
human health
Humans
Inhibitory Concentration 50
labdane
Malaysia
Medical sciences
medicinal plants
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
plant biochemistry
plant extracts
Plants, Medicinal - chemistry
Rhizome - chemistry
rhizomes
spectral analysis
vegetable crops
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Summary:A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, HSQC, HMBC) NMR techniques. All diarylheptanoids and scopoletin showed significant antioxidant activity. Zerumin B, demethoxycurcumin, bisdemethoxycurcumin, and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0500171