Immunohistological study for estrogenic activities of nitrophenols in diesel exhaust particles

We recently isolated 3-methyl-4-nitrophenol (4-nitro-m-cresol; PNMC) and 4-nitro-3-phenylphenol (PNMPP) from diesel exhaust particles (DEP) and identified them as vasodilators and xenoestrogens. The estrogenic activity of PNMC and PNMPP was further examined by using immunohistochemical staining of p...

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Bibliographic Details
Published in:Endocrine 2005-06, Vol.27 (1), p.33
Main Authors: Furuta, Chie, Li, ChunMei, Taneda, Shinji, Suzuki, Akira K, Kamata, Kazuyuki, Watanabe, Gen, Taya, Kazuyoshi
Format: Article
Language:English
Subjects:
Animals
Biphenyl Compounds - chemistry
Biphenyl Compounds - toxicity
Cresols - chemistry
Cresols - toxicity
Epithelial Cells - pathology
Estrogens, Non-Steroidal
Female
Immunohistochemistry
Nitrophenols - chemistry
Nitrophenols - toxicity
Ovariectomy
Proliferating Cell Nuclear Antigen - pharmacology
Rats
Rats, Wistar
Uterus - pathology
Vehicle Emissions - analysis
Vehicle Emissions - toxicity
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Summary:We recently isolated 3-methyl-4-nitrophenol (4-nitro-m-cresol; PNMC) and 4-nitro-3-phenylphenol (PNMPP) from diesel exhaust particles (DEP) and identified them as vasodilators and xenoestrogens. The estrogenic activity of PNMC and PNMPP was further examined by using immunohistochemical staining of proliferating cell nuclear antigen (PCNA) in uterine luminal epithelium of ovariectomized 25-d-old immature female rats injected with PNMC and PNMPP subcutaneously for 2 d. Significant increases were observed in uterine luminal epithelium in PCNA positive cells of animals receiving 10 and 100 mg/kg PNMC and 0.1 mg/kg PNMPP compared with controls. These results clearly show the estrogenic activity of PNMC and PNMPP by cell proliferation on the uterine luminal epithelium.
ISSN:1355-008X
DOI:10.1385/endo:27:1:033