Mitochondrial Ion Channels: Gatekeepers of Life and Death

Brian O’Rourke , Sonia Cortassa and Miguel A. Aon Institute of Molecular Cardiobiology, Division of Cardiology, The Johns Hopkins University, Baltimore, Maryland bor{at}jhmi.edu Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2005-10, Vol.20 (5), p.303-315
Main Authors: O'Rourke, Brian, Cortassa, Sonia, Aon, Miguel A
Format: Article
Language:English
Subjects:
Animals
Cell Survival - physiology
Energy Metabolism
Humans
Ion Channels - physiology
Ischemia - physiopathology
Mitochondria, Heart - metabolism
Myocardial Reperfusion Injury - prevention & control
Myocytes, Cardiac - physiology
Reactive Oxygen Species - metabolism
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Summary:Brian O’Rourke , Sonia Cortassa and Miguel A. Aon Institute of Molecular Cardiobiology, Division of Cardiology, The Johns Hopkins University, Baltimore, Maryland bor{at}jhmi.edu Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically active cells such as cardiomyocytes. Emerging evidence indicates that mitochondrial ion channels activated by reactive oxygen species can induce a mitochondrial "critical" state, which can scale to cause electrical and contractile dysfunction of the cardiac cell and, ultimately, the whole heart. Here we focus on how mitochondrial ion channels participate in life-and-death decisions of the cell and discuss the challenges ahead for translating recent findings into novel therapeutic applications.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00020.2005