NOVEL CYCLOSAL NUCLEOTIDES WITH REDUCED INHIBITORY POTENCY TOWARD HUMAN BUTYRYLCHOLINESTERASE

Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pr...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.519-522
Main Authors: Ducho, C., Jessel, S., Gisch, N., Balzarini, J., Meier, C.
Format: Article
Language:English
Subjects:
Antiviral Activity
Antiviral Agents - pharmacology
Binding Sites
Butyrylcholinesterase
Butyrylcholinesterase - chemistry
Chemistry, Pharmaceutical - methods
Cholinesterase Inhibitors - chemical synthesis
Cholinesterase Inhibitors - pharmacology
cycloSal
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Humans
Hydrogen-Ion Concentration
Hydrolysis
Models, Chemical
Nucleotides - chemistry
Nucleotides - pharmacology
Pronucleotides
Stereoisomerism
Temperature
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Summary:Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pronucleotide, bis-(cycloSal-d4TMP).
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-200061791