Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity

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Published in:Antimicrobial Agents and Chemotherapy 2005-11, Vol.49 (11), p.4721-4732
Main Authors: DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - drug therapy
Animals
Anti-HIV Agents
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Biological and medical sciences
Biological Availability
CCR5 Receptor Antagonists
Cyclohexanes
Cyclohexanes - pharmacokinetics
Cyclohexanes - pharmacology
Dogs
Drug Resistance, Viral
Drug Therapy, Combination
HeLa Cells
HIV-1
HIV-1 - drug effects
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Membrane Fusion - drug effects
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Receptors, CCR5 - metabolism
Triazoles
Triazoles - pharmacokinetics
Triazoles - pharmacology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.49.11.4721-4732.2005