N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus

Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2005, Vol.24 (8), p.1209
Main Authors: Du, Jinfa, Hollecker, Laurent, Shi, Junxing, Chun, Byoung-Kwon, Watanabe, Kyoichi A, Raymond, F Schinazi, Nachman, Tammy Y, Lostia, Stefania, Stuyver, Lieven J, Otto, Michael J
Format: Article
Language:English
Subjects:
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Cell Line, Tumor
Cytosine - analogs & derivatives
Cytosine - chemical synthesis
Cytosine - pharmacology
Dioxolanes - chemical synthesis
Dioxolanes - chemistry
Dioxolanes - pharmacology
Hepatitis B virus
Humans
Nucleosides - chemical synthesis
Nucleosides - chemistry
Nucleosides - pharmacology
Virus Replication - drug effects
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Summary:Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.
ISSN:1525-7770