A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line

Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-11, Vol.69 (11), p.2236-2239
Main Authors: Furutani, T.(Astellas Pharma Inc., Tsukuba, Ibaraki (Japan). Drug Discovery Research), Takeyama, K, Koutoku, H, Ito, S, Taniguchi, N, Suzuki, E, Kudoh, M, Shibasaki, M, Shikama, H, Kato, S
Format: Article
Language:English
Subjects:
androgen receptor
androgen receptor antagonist
ANDROGENE
ANDROGENOS
ANDROGENS
Androgens - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cell Proliferation - drug effects
CELLS
CELLULE
CELULAS
CRECIMIENTO
CROISSANCE
ESTEROIDES
EXPRESION GENICA
EXPRESSION DES GENES
Fundamental and applied biological sciences. Psychology
GENE EXPRESSION
GROWTH
HORMONE RECEPTORS
Humans
IMMUNOBLOTTING
Ligands
Male
NEOPLASMAS
NEOPLASME
NEOPLASMS
PROSTATA
PROSTATE
prostate cancer
Prostatic Neoplasms - pathology
RECEPTEUR D'HORMONE
RECEPTORES DE HORMONAS
Receptors, Androgen - genetics
Receptors, Androgen - physiology
RNA, Small Interfering - pharmacology
STEROIDE
STEROIDS
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Summary:Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.69.2236