Cytotoxic effects of the root extracts of Eurycoma longifolia Jack

The methanol, n‐butanol, chloroform and water extracts obtained from the root of Eurycoma longifolia Jack were assayed using methylene blue assay to evaluate its cytotoxic effect against KB, DU‐145, RD, MCF‐7, CaOV‐3, MDBK cell lines. The results showed that all the root extracts except the water ex...

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Bibliographic Details
Published in:Phytotherapy research 2005-11, Vol.19 (11), p.994-996
Main Authors: Nurhanan, M.Y, Hawariah, L.P.A, Ilham, A.M, Shukri, M.A.M
Format: Article
Language:English
Subjects:
9-methoxycanthin-6-one
Biological and medical sciences
cancer cell lines
Carbolines - analysis
Carbolines - toxicity
Cell Line, Tumor - drug effects
cytotoxic
Eurycoma
Eurycoma longifolia Jack
General pharmacology
Humans
Medical sciences
Methylene Blue
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - toxicity
Plant Roots - chemistry
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Summary:The methanol, n‐butanol, chloroform and water extracts obtained from the root of Eurycoma longifolia Jack were assayed using methylene blue assay to evaluate its cytotoxic effect against KB, DU‐145, RD, MCF‐7, CaOV‐3, MDBK cell lines. The results showed that all the root extracts except the water extract of E. longifolia produced significant cytotoxic effect on these cell lines. However, no significant cytotoxic effect was detected on MDBK (kidney) normal cell line. 9‐methoxycanthin‐6‐one, an alkaloid, was detected in each extract with different intensities by reversed‐phase high performance liquid chromatography. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1759