CC Chemokine Receptor 5 Is Important in Control of Parasite Replication and Acute Cardiac Inflammation following Infection with Trypanosoma cruzi

Infection of susceptible mice with the Colombiana strain of Trypanosoma cruzi results in an orchestrated expression of chemokines and chemokine receptors within the heart that coincides with parasite burden and cellular infiltration. CC chemokine receptor 5 (CCR5) is prominently expressed during bot...

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Bibliographic Details
Published in:Infection and Immunity 2006, Vol.74 (1), p.135-143
Main Authors: Hardison, Jenny L, Wrightsman, Ruth A, Carpenter, Philip M, Kuziel, William A, Lane, Thomas E, Manning, Jerry E
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Biological and medical sciences
Chagas Disease - immunology
Chagas Disease - metabolism
Chagas Disease - mortality
Chemokines - biosynthesis
Chemokines - genetics
Female
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
Human protozoal diseases
Humans
Infectious diseases
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Myocarditis - immunology
Myocarditis - metabolism
Myocarditis - parasitology
Parasitic diseases
Protozoal diseases
Receptors, CCR5 - deficiency
Receptors, CCR5 - genetics
Receptors, CCR5 - physiology
T-Lymphocytes - immunology
Trypanosoma cruzi
Trypanosoma cruzi - growth & development
Trypanosoma cruzi - immunology
Trypanosomiasis
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Summary:Infection of susceptible mice with the Colombiana strain of Trypanosoma cruzi results in an orchestrated expression of chemokines and chemokine receptors within the heart that coincides with parasite burden and cellular infiltration. CC chemokine receptor 5 (CCR5) is prominently expressed during both acute and chronic disease, suggesting a role in regulating leukocyte trafficking and accumulation within the heart following T. cruzi infection. To better understand the functional role of CCR5 and its ligands with regard to both host defense and/or disease, CCR5[superscript -/-] mice were infected with T. cruzi, and the disease severity was evaluated. Infected CCR5[superscript -/-] mice develop significantly higher levels of parasitemia (P
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.74.1.135-143.2006