Neuronal Activity Related to Elapsed Time in Prefrontal Cortex

Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland Submitted 28 September 2005; accepted in final form 11 January 2006 We studied prefrontal cortex activity during a saccade task. On each trial, one of three delay periods elapsed between the onset of a visual...

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Bibliographic Details
Published in:Journal of neurophysiology 2006-05, Vol.95 (5), p.3281-3285
Main Authors: Genovesio, Aldo, Tsujimoto, Satoshi, Wise, Steven P
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Macaca mulatta
Neurons - classification
Neurons - physiology
Photic Stimulation - methods
Prefrontal Cortex - cytology
Psychomotor Performance
Reaction Time - physiology
Saccades - physiology
Time Factors
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Summary:Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland Submitted 28 September 2005; accepted in final form 11 January 2006 We studied prefrontal cortex activity during a saccade task. On each trial, one of three delay periods elapsed between the onset of a visual stimulus and its offset, which triggered a saccade. After stimulus offset, many neurons showed phasic increases in activity that depended on the duration of the preceding delay period. This delay-dependent activity varied only weakly with reaction time and instead appeared to reflect a more general aspect of elapsed time. Address for reprint requests and other correspondence: Steven P. Wise, Laboratory of Systems Neuroscience, National Institute of Mental Health, Building 49, Room B1EE17, 49 Convent Drive, MSC 4401, Bethesda, MD 20892-4401 (Email: stevenwise{at}mail.nih.gov )
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.01011.2005