A Review of the Effects and Mechanisms of Polyphenolics in Cancer

This paper is a comprehensive review of the effects of bioactive polyphenolic compounds commonly found in many fruits and vegetables on cancer. These include the pheniolic acids, anthocyanins, catechins, stilbenes and several other flavonoids. We have attempted to compile information from most of th...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in food science and nutrition 2006-03, Vol.46 (2), p.161-183
Main Authors: Nichenametla, Sailendra N., Taruscio, Todd G., Barney, Danny L., Exon, Jerry H.
Format: Article
Language:English
Subjects:
Animals
anthocyanins
Anthocyanins - administration & dosage
Anthocyanins - pharmacokinetics
Biological Availability
Catechin - administration & dosage
Catechin - pharmacokinetics
catechins
Cell Line, Tumor
Chemoprevention
Flavonoids - administration & dosage
Flavonoids - classification
Flavonoids - pharmacokinetics
Flavonols - administration & dosage
Flavonols - pharmacokinetics
Fruit - chemistry
Humans
Neoplasms - prevention & control
Neoplasms - therapy
phenolic acids
Phenols - administration & dosage
Phenols - classification
Phenols - pharmacokinetics
Polyphenols
stilbenes
Stilbenes - administration & dosage
Stilbenes - pharmacokinetics
Vegetables - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper is a comprehensive review of the effects of bioactive polyphenolic compounds commonly found in many fruits and vegetables on cancer. These include the pheniolic acids, anthocyanins, catechins, stilbenes and several other flavonoids. We have attempted to compile information from most of the major studies in this area into one source. The review encompasses the occurrence and bioavailability of the polyphenolics, the in vitro and in vivo evidence for their effects on cancer, both positive and negative, and the various mechanisms by which the chemicals may exert their effects. Although most of the work done to date indicates a chemopreventative activity of these compounds, there are some studies that show cancer-inducing or no effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis, effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408390591000541