Neuroprotective 2-(2-Phenylethyl)chromones of Imperata cylindrica

Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylch...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-02, Vol.69 (2), p.290-291
Main Authors: Yoon, J.S, Lee, M.K, Sung, S.H, Kim, Y.C
Format: Article
Language:English
Subjects:
2-(phenylethyl)chromone
Adrenal Cortex - cytology
Adrenal Cortex - drug effects
Animals
Biological and medical sciences
Cells, Cultured
chemical structure
Chromones - chemistry
Chromones - isolation & purification
Chromones - pharmacology
flavonoids
General pharmacology
Glutamic Acid - pharmacology
Imperata cylindrica
Korea
Medical sciences
medicinal plants
neurons
Neuroprotective Agents - chemistry
Neuroprotective Agents - isolation & purification
Neuroprotective Agents - pharmacology
neuroprotective effect
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Poaceae - chemistry
Rats
Rhizome
spectral analysis
traditional medicine
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Summary:Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0503808