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The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia

Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently ill-defined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patien...

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Published in:	Haematologica (Roma) 2006-04, Vol.91 (4), p.574
Main Authors:	Gamberale, R, Fernandez-Calotti, P, Sanchez-Avalos, J, Alberto, MF, Geffner, J, Giordano, M
Format:	Article
Language:	English
Subjects:	Anemia, Hemolytic, Autoimmune - chemically induced Anemia, Hemolytic, Autoimmune - etiology Case-Control Studies Humans Interferon-gamma - biosynthesis Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphocytes - drug effects Vidarabine - adverse effects Vidarabine - analogs & derivatives Vidarabine - pharmacology
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container_title	Haematologica (Roma)
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creator	Gamberale, R Fernandez-Calotti, P Sanchez-Avalos, J Alberto, MF Geffner, J Giordano, M
description	Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently ill-defined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-gamma, a key cytokine in the pathogenesis of AHA.
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subjects	Anemia, Hemolytic, Autoimmune - chemically induced Anemia, Hemolytic, Autoimmune - etiology Case-Control Studies Humans Interferon-gamma - biosynthesis Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphocytes - drug effects Vidarabine - adverse effects Vidarabine - analogs & derivatives Vidarabine - pharmacology
title	The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia
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