Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin

Partially purified paeoniflorin (PF), a new cosmetic ingredient from roots of Paeoniae lactiflora, has been developed. Its paeoniflorin content is about 64%, far higher than that of conventional, cosmetic-grade peony root extracts (approximately 10%). In this report, we studied the effects of PF on...

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Bibliographic Details
Published in:Journal of cosmetic science 2006, Vol.57 (1), p.57-64
Main Authors: LEE, Sanghwa, JUN MAN LIM, MU HYUN JIN, HYUNG KOOK PARK, EUI JUNG LEE, SANGJIN KANG, YOUN SOO KIM, WAN GOO CHO
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adult
Animals
Applied sciences
Benzoates - pharmacology
Biological and medical sciences
Bridged-Ring Compounds - pharmacology
Cells, Cultured
Chemical industry and chemicals
Comet Assay
Cosmetics, toiletries
Diseases of the skin. Cosmetics
DNA Damage - physiology
Double-Blind Method
Exact sciences and technology
Female
Glucosides - pharmacology
Humans
Keratinocytes - drug effects
Keratinocytes - radiation effects
Male
Medical sciences
Mice
Mice, Hairless
Middle Aged
Monoterpenes
Plant Extracts - pharmacology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Random Allocation
Skin Aging - drug effects
Skin Aging - pathology
Skin Aging - radiation effects
Ultraviolet Rays - adverse effects
Washing products. Cosmetics and toiletries. Perfumes
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Summary:Partially purified paeoniflorin (PF), a new cosmetic ingredient from roots of Paeoniae lactiflora, has been developed. Its paeoniflorin content is about 64%, far higher than that of conventional, cosmetic-grade peony root extracts (approximately 10%). In this report, we studied the effects of PF on UV-induced DNA damage in both cultured human keratinocytes and hairless mouse skin. We also investigated the anti-wrinkle effects of PF-containing cosmetic preparations on human skin. From the in vitro and in vivo comet assay, it was revealed that PF protected cells from DNA damage induced by ultraviolet B (UVB) irradiation in both cultured normal human keratinocytes (19.4% decrease at 0.001%) and hairless mouse skin keratinocytes (41% decrease at 0.01%). An eight-week clinical trial using 0.5% PF-containing formulation with 20 volunteers resulted in a statistically significant reduction in facial wrinkles (p < 0.05). These results suggest that the partially purified paeoniflorin has potent anti-aging and anti-wrinkle activities and should be a useful ingredient for these purposes.
ISSN:1525-7886
2689-5153