DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY

Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompt...

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Bibliographic Details
Published in:Experimental lung research 2005-11, Vol.31 (9-10), p.807-818
Main Authors: Nadkarni, Priya P., Kulkarni, Girish S., Cerreta, Joseph M., Ma, Shuren, Cantor, Jerome O.
Format: Article
Language:English
Subjects:
Aerosols
Animals
anti-inflammatory
Apoptosis - drug effects
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Cricetinae
endotoxin
Endotoxins - toxicity
hyaluronan
Hyaluronic Acid - administration & dosage
Hyaluronic Acid - pharmacology
inflammation
lung
Lung - drug effects
Medical sciences
Mesocricetus
Neutrophils - drug effects
Pharmacology. Drug treatments
Pneumology
Receptors, Tumor Necrosis Factor, Type I - drug effects
Respiratory system
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Summary:Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902140600574942