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DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY
Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompt...
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| Published in: | Experimental lung research 2005-11, Vol.31 (9-10), p.807-818 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c434t-1c09236f160b5d12297d532d74000b4ff281889ae83caa8574cc0e6c78fdbe403 |
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| cites | cdi_FETCH-LOGICAL-c434t-1c09236f160b5d12297d532d74000b4ff281889ae83caa8574cc0e6c78fdbe403 |
| container_end_page | 818 |
| container_issue | 9-10 |
| container_start_page | 807 |
| container_title | Experimental lung research |
| container_volume | 31 |
| creator | Nadkarni, Priya P. Kulkarni, Girish S. Cerreta, Joseph M. Ma, Shuren Cantor, Jerome O. |
| description | Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect. |
| doi_str_mv | 10.1080/01902140600574942 |
| format | article |
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Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. 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Drug treatments ; Pneumology ; Receptors, Tumor Necrosis Factor, Type I - drug effects ; Respiratory system</subject><ispartof>Experimental lung research, 2005-11, Vol.31 (9-10), p.807-818</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-1c09236f160b5d12297d532d74000b4ff281889ae83caa8574cc0e6c78fdbe403</citedby><cites>FETCH-LOGICAL-c434t-1c09236f160b5d12297d532d74000b4ff281889ae83caa8574cc0e6c78fdbe403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17676695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16684714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadkarni, Priya P.</creatorcontrib><creatorcontrib>Kulkarni, Girish S.</creatorcontrib><creatorcontrib>Cerreta, Joseph M.</creatorcontrib><creatorcontrib>Ma, Shuren</creatorcontrib><creatorcontrib>Cantor, Jerome O.</creatorcontrib><title>DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY</title><title>Experimental lung research</title><addtitle>Exp Lung Res</addtitle><description>Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.</description><subject>Aerosols</subject><subject>Animals</subject><subject>anti-inflammatory</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cricetinae</subject><subject>endotoxin</subject><subject>Endotoxins - toxicity</subject><subject>hyaluronan</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>inflammation</subject><subject>lung</subject><subject>Lung - drug effects</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Neutrophils - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumology</subject><subject>Receptors, Tumor Necrosis Factor, Type I - drug effects</subject><subject>Respiratory system</subject><issn>0190-2148</issn><issn>1521-0499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRtH78AC-Si8fo7Gaz2aCXkKRtJM1C24B6idtNQitpI5uK9N-7pZUigqc5zPO8zLwIXWO4w8DhHrAPBFNgAK5HfUqOUA-7BNtAff8Y9bZ72wD8DJ133TsAEJezU3SGGePUw7SH3qIkHIqpGIl8YsX9fhxOLdG3gngsJiJNXuPIGr4EaT4WWZBZSWYF1jAYTabx2BqJKE63cJxFJuE5yewki_LQKGmeDQz8lI9fLtFJLZuuutrPC5T342k4tFMxSMIgtRV16NrGCnzisBozmLklJsT3StchpUfN1TNa14Rjzn1ZcUdJyc27SkHFlMfrclZRcC4Q3uUq3XadruriQy-WUm8KDMW2reJPW8a52Tkfn7NlVR6MfT0GuN0DslOyqbVcqUV34DzmMea7hnvccYtV3eql_Gp1UxZruWla_SM5_93x8EufV7JZz5XUVfHefuqV6e2fL74B7zKNng</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Nadkarni, Priya P.</creator><creator>Kulkarni, Girish S.</creator><creator>Cerreta, Joseph M.</creator><creator>Ma, Shuren</creator><creator>Cantor, Jerome O.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20051101</creationdate><title>DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY</title><author>Nadkarni, Priya P. ; Kulkarni, Girish S. ; Cerreta, Joseph M. ; Ma, Shuren ; Cantor, Jerome O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-1c09236f160b5d12297d532d74000b4ff281889ae83caa8574cc0e6c78fdbe403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aerosols</topic><topic>Animals</topic><topic>anti-inflammatory</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cricetinae</topic><topic>endotoxin</topic><topic>Endotoxins - toxicity</topic><topic>hyaluronan</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>inflammation</topic><topic>lung</topic><topic>Lung - drug effects</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Neutrophils - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Pneumology</topic><topic>Receptors, Tumor Necrosis Factor, Type I - drug effects</topic><topic>Respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadkarni, Priya P.</creatorcontrib><creatorcontrib>Kulkarni, Girish S.</creatorcontrib><creatorcontrib>Cerreta, Joseph M.</creatorcontrib><creatorcontrib>Ma, Shuren</creatorcontrib><creatorcontrib>Cantor, Jerome O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental lung research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadkarni, Priya P.</au><au>Kulkarni, Girish S.</au><au>Cerreta, Joseph M.</au><au>Ma, Shuren</au><au>Cantor, Jerome O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY</atitle><jtitle>Experimental lung research</jtitle><addtitle>Exp Lung Res</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>31</volume><issue>9-10</issue><spage>807</spage><epage>818</epage><pages>807-818</pages><issn>0190-2148</issn><eissn>1521-0499</eissn><coden>EXLRDA</coden><abstract>Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>16684714</pmid><doi>10.1080/01902140600574942</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-2148 |
| ispartof | Experimental lung research, 2005-11, Vol.31 (9-10), p.807-818 |
| issn | 0190-2148 1521-0499 |
| language | eng |
| recordid | cdi_pubmed_primary_16684714 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Aerosols Animals anti-inflammatory Apoptosis - drug effects Biological and medical sciences Chronic obstructive pulmonary disease, asthma Cricetinae endotoxin Endotoxins - toxicity hyaluronan Hyaluronic Acid - administration & dosage Hyaluronic Acid - pharmacology inflammation lung Lung - drug effects Medical sciences Mesocricetus Neutrophils - drug effects Pharmacology. Drug treatments Pneumology Receptors, Tumor Necrosis Factor, Type I - drug effects Respiratory system |
| title | DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY |
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