Shiga Toxin of Enterohemorrhagic Escherichia coli Type O157:H7 Promotes Intestinal Colonization

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen that can cause bloody diarrhea and, occasionally, acute renal failure as a consequence of Shiga toxin (Stx) production by the organism. Stxs are potent cytotoxins that are lethal to animals at low doses. Thus, Stxs not only h...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-06, Vol.103 (25), p.9667-9672
Main Authors: Robinson, Cory M., Sinclair, James F., Smith, Michael J., O'Brien, Alison D.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Bacteria
Bacterial Adhesion
Biological Sciences
Cell Line, Tumor
Cell nucleolus
Cultured cells
Epithelial cells
Epithelial Cells - cytology
Epithelial Cells - drug effects
Escherichia coli
Escherichia coli O157 - cytology
Escherichia coli O157 - genetics
Escherichia coli O157 - growth & development
Escherichia coli O157 - metabolism
Gene Expression Regulation, Bacterial
Infections
Intestines - drug effects
Intestines - microbiology
Mice
Mice, Inbred BALB C
Microbial colonization
Mutation - genetics
Nucleolin
Phosphoproteins - metabolism
Protein Subunits - metabolism
Protein Subunits - toxicity
Receptors
RNA-Binding Proteins - metabolism
Shiga Toxin - genetics
Shiga Toxin - metabolism
Shiga Toxin - toxicity
Toxins
Vero cells
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Summary:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen that can cause bloody diarrhea and, occasionally, acute renal failure as a consequence of Shiga toxin (Stx) production by the organism. Stxs are potent cytotoxins that are lethal to animals at low doses. Thus, Stxs not only harm the host but, as reported here, also significantly enhance the capacity of EHEC O157:H7 to adhere to epithelial cells and to colonize the intestines of mice. Tissue culture experiments showed that this toxin-mediated increase in bacterial adherence correlated with an Stx-evoked increase in a eukaryotic receptor for the EHEC O157:H7 attachment factor intimin.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0602359103