Sublethal Effects of Profenofos on Locomotor Behavior and Gill Architecture of the Mosquito Fish,Gambusia affinis

• Published in: Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2006-01, Vol.29 (3), p.255-267
• Main Authors: Venkateswara Rao, J., Begum, Ghousia, Jakka, N. M., Srikanth, K., Nageswara Rao, R.
• Format: Article
• Language: English
• Subjects: Acetylcholinesterase - metabolism; AChE; Agnatha. Pisces; Algorithms; Animal, plant and microbial ecology; Animals; Applied ecology; Behavior; Bioaccumulation; Biological and medical sciences; Culicidae; Cyprinodontiformes - physiology; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; Fish; Fundamental and applied biological sciences. Psychology; Gambusia affinis; Gill; Gills - drug effects; Gills - enzymology; Gills - pathology; Insecticides - pharmacokinetics; Insecticides - toxicity; Lethal Dose 50; Motor Activity - drug effects; Organothiophosphates - pharmacokinetics; Organothiophosphates - toxicity; Profenofos; Tissue Distribution
• ISSN: 0148-0545; 1525-6014
• DOI: 10.1080/01480540600651543

Subacute studies of profenofos on mosquito fish, Gambusia affinis, were carried out for 20 days to assess the locomotor behavior and structural integrity of gill in relation to bioaccumulation and targeted enzyme acetylcholinesterase (AChE; EC 3.1.1.7). The sublethal concentration of 0.13 mg/L (1/5 of LC50) altered locomotor behavior such as distance traveled and swimming speed in exposed fish. This could be due to inhibition in the activity of acetylcholinesterase and deformities in the primary and secondary lamella of gill. The bioaccumulation values indicated that the accumulation of profenofos was highest in viscera followed by head and body. The average bioconcentration factor values are 254.83, 6.18, and 2.52 μg/g for viscera, head, and body. The findings revealed that profenofos is highly toxic even at sublethal concentrations to the mosquito fish, Gambusia affinis.