Becker's nevus associated with epidermal nevus: another example of twin spotting?

Linear epidermal nevi are believed to be caused by an autosomal dominant lethal mutation that can only be expressed by mosaicism. Becker's nevus can be explained by paradominant inheritance which is only manifested clinically by an acquired loss of heterozygosity. We present the case of a 16-ye...

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Bibliographic Details
Published in:Actas dermo-sifiliográficas 2006-04, Vol.97 (3), p.200
Main Authors: Rodríguez-Díaz, Eloy, Alvarez-Cuesta, César-Cosme, Blanco, Susana, Galache, Cristina, Hidalgo, Yolanda
Format: Article
Language:Spanish
Subjects:
Adolescent
Female
Hamartoma - embryology
Hamartoma - genetics
Head and Neck Neoplasms - embryology
Head and Neck Neoplasms - genetics
Humans
Loss of Heterozygosity
Mosaicism
Nevus, Pigmented - embryology
Nevus, Pigmented - genetics
Shoulder
Skin Diseases - embryology
Skin Diseases - genetics
Skin Neoplasms - embryology
Skin Neoplasms - genetics
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Summary:Linear epidermal nevi are believed to be caused by an autosomal dominant lethal mutation that can only be expressed by mosaicism. Becker's nevus can be explained by paradominant inheritance which is only manifested clinically by an acquired loss of heterozygosity. We present the case of a 16-year-old female with an epidermal nevus located on the left side of the neck, and also a Becker's nevus located on the ipsilateral shoulder. It is interesting to speculate that this supposed double mosaicism could be another example of "twin spotting" or non-allelic didymosis, although the possibility that this is a chance association cannot be ruled out, as the lesions are not closely associated.
ISSN:0001-7310
DOI:10.1016/S0001-7310(06)73380-4