Effects of piracetam supplementation on cochlear damage occurring in guinea pigs exposed to irradiation

In this study we aimed to determine the role of piracetam (PIR) in preventing radiation induced cochlear damage after total-cranium irradiation (radiotherapy; RT). Male albino guinea pigs used in the study were randomly divided into three groups. Group 1 (Control group) (n=11) received neither PIR n...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2006-07, Vol.29 (7), p.1460
Main Authors: Altas, Enver, Ertekin, Mustafa Vecdi, Kuduban, Ozan, Gundogdu, Cemal, Demirci, Elif, Sutbeyaz, Yavuz
Format: Article
Language:English
Subjects:
Animals
Cochlea - blood supply
Cochlea - drug effects
Cochlea - pathology
Cochlea - radiation effects
Disease Models, Animal
Edema - diagnostic imaging
Edema - prevention & control
Guinea Pigs
Organ of Corti - drug effects
Organ of Corti - pathology
Organ of Corti - radiation effects
Piracetam - pharmacology
Radiation-Protective Agents - pharmacology
Radionuclide Imaging
Reference Values
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Summary:In this study we aimed to determine the role of piracetam (PIR) in preventing radiation induced cochlear damage after total-cranium irradiation (radiotherapy; RT). Male albino guinea pigs used in the study were randomly divided into three groups. Group 1 (Control group) (n=11) received neither PIR nor irradiation, but received saline solution intraperitoneally (i.p.) and received sham irradiation. Group 2 (RT group) (n=32) was exposed to total cranium irradiation of 33 Gy in 5 fractions of 6.6 Gy/d for five successive days, with a calculated (alpha/beta=3.5) biological effective dose of fractionated irradiation equal to 60 Gy conventional fractionation, then received saline solution for five successive days i.p. Group 3 (PIR+RT group) (n=33) received total cranium irradiation, plus 350 mg/kg per day PIR for five successive days i.p. After the last dose of RT, the guinea pigs were all sacrificed at the 4th, 24th and 96th hours, respectively. Their cochleas were enucleated for histopathologic examination. It was observed that total cranium irradiation (RT group) promoted degeneration in stria vascularis (SV), spiral ganglion cells (SG), outer hair cells (OHC) and inner hair cell (IHC) of cochleas at these times (p0.05) and IHC at 4th, 24th hours (p>0.05), there was a significant difference on radiation-induced cochlear degeneration in SV and OHC at 24th and 96th hours (p
ISSN:0918-6158