On multiscale approaches to three-dimensional modelling of morphogenesis

In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Royal Society interface 2005-06, Vol.2 (3), p.237-253
Main Authors: Chaturvedi, R, Huang, C, Kazmierczak, B, Schneider, T, Izaguirre, J.A, Glimm, T, Hentschel, H.G.E, Glazier, J.A, Newman, S.A, Alber, M.S
Format: Article
Language:English
Subjects:
Animals
Cattle
Cell Death
Cell Division
Cell Dynamics
Cell Physiological Phenomena
Cellular Potts Model
Computational Biology
Models, Biological
Morphogenesis
Morphogenesis - physiology
Organogenesis
Physiology - methods
Systems Biology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical mechanics, the Cellular Potts Model, with a continuum reaction-diffusion model and a state automaton with well-defined conditions for cell differentiation transitions to model genetic regulation. This environment allows us to rapidly and compactly create computational models of a class of complex-developmental phenomena. To illustrate model development, we simulate a simplified version of the formation of the skeletal pattern in a growing embryonic vertebrate limb.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2005.0033