Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice

DNA synthesis in a transplanted hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was significantly reduced (P less than 0.01) in rats maintained on diets low (0.4 mug/g) or high (greater than or equal to 500 mug/g) in zinc when compared with control animals given 60 mug zinc/g. 3-Methylc...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1975-07, Vol.55 (1), p.195
Main Authors: Duncan, J R, Dreosti, I E
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Hepatocellular - metabolism
Depression, Chemical
DNA, Neoplasm - biosynthesis
Dose-Response Relationship, Drug
Female
Liver Neoplasms - metabolism
Methylcholanthrene - antagonists & inhibitors
Mice
Neoplasms, Experimental
Rats
Thymidine - metabolism
Zinc - metabolism
Zinc - pharmacology
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Summary:DNA synthesis in a transplanted hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was significantly reduced (P less than 0.01) in rats maintained on diets low (0.4 mug/g) or high (greater than or equal to 500 mug/g) in zinc when compared with control animals given 60 mug zinc/g. 3-Methylcholanthrene-induced carcinogenesis was considerably lowered in mice receiving the same low or high zinc diets during the induction periods.
ISSN:0027-8874
DOI:10.1093/jnci/55.1.195